Fig. 1. Effects of MitoQ on insulin secretion in INS-1E cells exposed to glucose or palmitate conditions. Cells were incubated in the presence or absence of 0.5mM palmitate for 24h and then exposed to MitoQ for 3h. Subsequently, they were incubated in HBSS containing 3mM or 15mM glucose. Insulin secretion was evaluated by measuring insulin concentrations in the conditioned medium with an ELISA assay. Data are expressed as insulin secretion in total protein content (mean ▒ SEM, n=8-11). *p<0.05 with regard to MitoQ-treated cells in the 3mM glucose condition.