**Fig. 4.** Beta and alpha diversity
ordination plots. (A-C) Measurement and comparison of beta diversity in various
groups using both unweighted and weighted UniFrac (phylogenetic) distance
matrices. Data were plotted using PCoA ordination method utilizing the OTUs as
the basic units. The percentage of variability of each principal coordinates
(PC) has been explained on the axis of each plot. Each colored circle or
triangle represents a sample from a group, as indicated. The probability
distribution has been represented by the ellipses. (D-F) Measurement of the
intra-sample variation by alpha diversity analysis. The alpha diversity metrics
use the counts (richness) and distribution (evenness, Simpson Index) of the
OTUs within a sample as the basic values for these calculations. HC: Healthy
controls; NTM: Women with NTM lung disease only; NTM-BCa: Women with both NTM
lung disease and breast cancer.