**Fig. 7.** Alpha and beta diversity
ordination plots. (A) Measurement of the intra-sample diversity by alpha
diversity method. The alpha diversity metrics use the counts (richness) and
distribution (evenness, Shannon Index) of the OTUs within a sample as the basic
values for these calculations. (B) Measurement and comparison of beta diversity
in various groups using weighted UniFrac (phylogenitic) distance metrics. Data
were plotted using PCoA ordination method utilizing the OTUs as the basic
units. The percentage of variability of each principal coordinates (PC) has
been explained on the axis of the plot. Each colored circle represents a sample
from a group, as indicated. The probability distribution has been represented
by the ellipses. (C-D) Exclusive abundance of various genera and phyla in the
circulating exosomes. A minimum average abundance of 1% was considered for the
categorization of the top taxa.