Fig. 6. Docking simulation for verapamil within the pore cavity of hKv1.5 channel. (A) The side view of the hKv1.5 channel pore region with verapamil binding at the lowest free energy of binding (-8.41 kcal/mol). (B) A close-up view of the binding area of verapamil shown in panel (A). The amino acids predicted to reside within 4.5 Å of verapamil are shown as a skeletal model, and verapamil is drawn as a space-filling model.