Fig. 6. Disruption of p53-Mdm2 interaction up-regulates p38-Wip1 loop. Representative Western blotting of p38-Wip1 loop consisting molecules in HTR8/SVneo cells pretreated with 2 ÁM NVP-CGM097 (NVP) for 6 h followed by 24 h of HII or SIB in fresh medium, Kruskal-Wallis test, Dunn's multiple comparison test for p-p53/p53 and one-way ANOVA, Sidak's multiple comparison test for others. β-actin was used as loading control. n=4, β-actin was used as loading control. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Experiments were performed in triplicate.