Fig. 8. p53-Mdm2 interaction is required for activation of the p38-Wip1 loop. Western blotting of p38-Wip1 loop consisting molecules in HTR8/SVneo cells incubated with 4 ÁM SB202190 alone, 2 ÁM NVP alone, or a combination of SB202190 and NVP in normoxia, HII and SIB for 24 h, Kruskal-Wallis test, Dunn's multiple comparison test for p-p53/p53 in HII and SIB, and one-way ANOVA, Dunnett-t multiple comparison test for others. n=4, β-actin was used as loading control. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Experiments were performed in triplicate.