Fig. 3. CRT0066101 suppresses TNBC growth in vivo. CRT0066101 inhibited triple-negative breast tumor growth in a xenograft mouse model using (A) MDA-MB-231 and (B) MDA-MB-468 cells. Palpable tumor growth across time was measured every week from the time tumor was palpable until the animals were sacrificed (week 6). Tumor images at the end point (week 6) are shown and palpable tumor volumes were measured by width and length with a Vernier caliper and calculated using the formula volume = (length width2)/2. Data represent the mean SEM. **P<0.01 and ***P<0.001 by t test.