Fig. 7. Effect of SST14 on SSTR receptor expression under conditions of lipid and cytokine toxicity. Sstr mRNA expression was assessed in MIN6 beta cells by qPCR under normal culture conditions (panel A) or following pre-treatment with 1 μmol/l SST14 for 48h followed by 20h exposure to 0.5 mmol/l palmitate (PAL) or cytokines (50 U/ml IL1β and 1000 U/ml TNFα), with or without SST14. Panels B-E show results for Sstr 1, 2, 3, and 5, respectively. *P<0.05, vs control (one way ANOVA and Bonferroni's multiple comparisons test). Data presented as means ▒ SEM of 6-8 separate experiments.