Fig. 1. Elamipretide improves stenotic kidney (STK) function and blunts fibrosis. A. Atherosclerotic renal artery stenosis (ARAS) pigs showed a decrease in both STK and overall kidney function. Elamipretide improved serum creatinine, STK glomerular filtration rate (GFR), and renal blood flow (RBF). B. ARAS developed STK fibrosis (trichrome, blue) and glomerulosclerosis, which elamipretide alleviated. N, Normal; N+E, Normal+elamipretide; A, ARAS; A+E, ARAS+elamipretide. *P<0.05 vs. Normal, ćP<0.05 vs. ARAS.