A growing research collection in Cellular Physiology and Biochemistry exploring physical and mechanical approaches for solid tumor treatment, including biomechanics, computational simulation, immune modulation, blood-brain barrier interaction, neuroprotection and transcranial application.
Tumor Destructive Mechanical Impulse (TMI) represents an experimental physical and mechanical treatment concept for solid tumors. The approach explores whether focused mechanical impulse application may induce direct tumor destruction, vascular and microenvironmental changes, as well as local and systemic immunological responses.
This collection brings together published CPB articles related to TMI, biomechanics, neuro-oncology, blood-brain barrier interaction, neuromodulation and other physical treatment modalities.
Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part I: Animal Experiments, Clinical Application and Immunological Abscopal Effect
Experimental and early clinical observations exploring TMI application, tumor destruction and possible immunological abscopal effects.
Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part II: Biomechanics, Computational Simulation, Technical Generator and Applicator Design, and Physiological Effect
Focus on biomechanical principles, simulation, applicator design and physiological implications of TMI treatment.
Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part III: Transcranial Application, Immune Profile, Blood-Brain Barrier, Neuroprotection, Neuromodulation and Neurostimulation
Exploratory transcranial application of TMI with focus on neuro-oncology, blood-brain barrier interaction and neuromodulatory effects.
Ongoing work in this area includes translational and clinical approaches related to neuro-oncology, glioblastoma treatment, immune profiling, biomechanical optimization and further exploration of physical tumor treatment strategies.
CPB welcomes additional mechanistic, translational and clinically oriented contributions related to physical and mechanical approaches in cancer therapy.
TMI is an experimental physical and mechanical approach for the treatment of solid tumors using focused mechanical impulse application.
Published experimental and exploratory clinical observations discuss potential local and systemic immune responses following TMI treatment.
Part III of this CPB collection discusses transcranial application, blood-brain barrier interaction and neuromodulatory aspects in neuro-oncology.