Corresponding Author: Yunhui Liu

Department of Neurosurgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Road, Heping District, Shenyang 110004 (China)
Tel. +86 024 96615-36111, Fax +86 024 2295 8989,E-Mail


In the article “Roundabout4 Suppresses Glioma-Induced Endothelial Cell Proliferation, Migration and Tube Formation in Vitro by Inhibiting VEGR2-Mediated PI3K/AKT and FAK Signaling Pathways” [Cell Physiol Biochem 2015;35:1689-1705. DOI: 10.1159/000373982] by Cai et al., a number of incorrect panels were included in Figure 4B and Figure 8B during Figure assembly. Specifically, Figure 4B Robo4(+) NC (endothelial cell medium), Robo4(-) NC (endothelial cell medium), Robo4(-) (endothelial cell medium) and Robo4(-) NC (glioma conditioned medium) representative images were incorrect in the original article. Figure 8B Robo4(-)+ FAK inhibitor 14 representative image was incorrect in the original article.

The corrected Figure 4 and Figure 8 are shown here.

Fig. 4. Effect of Robo4 on glioma-induced endothelial cell proliferation, migration, and tube formation in vitro. Endothelial Cell viability was measured by CCK-8 proliferation assay, and results were expressed as percent viability, from left to right, the lanes are in control, Robo4(+) NC, Robo4(+), Robo4(-) NC and Robo4(-), respectively. Migration of endothelial cell was measured by transwell migration assay, and results were expressed as the number of migrated cells per field (magnification, ×200; scale bar, 100µm). Tube formation of ECs was measured, and results were expressed as relative tubule length and number of branches (magnification, ×100; scale bar, 100µm). Data represent means ± SD (n = 5, each). *P<0.05 vs. Robo (+) NC group, #P<0.05 vs. Robo (-) NC group.

Fig. 8. VEGR2 mediate PI3K/AKT and FAK signaling pathways were involved in the Robo4-regulated glioma angiogenesis in vitro. After ECs in glioma conditioned medium were pretreated with VEGFR2 inhibitor SU-1498(10uM), AKT inhibitor LY294002(10uM) and FAK inhibitor 14(5uM) for 24 hours, ECs proliferation (A), migration (B) and Tube formation (C) are showed. Data represent mean ± SD (n = 5, each). *P<0.05 vs. Robo4 (-) NC group, #P<0.05 vs. Robo4 (-) group.